Adapalene for Acne: How This Over-the-Counter Retinoid Works
By Michael C. · Written and reviewed by Michael C.
Acne treatment · Published 2026-07-05 · 10 min read · 1865 words · Updated 2026-09-08
Adapalene is a synthetic retinoid that prevents new blockages in pores, making it one of the most effective non-prescription acne treatments available.
Key takeaways
- Adapalene is a synthetic third-generation retinoid available over the counter at 0.1 percent in South Africa.
- It prevents new blockages in pores rather than treating existing pimples, so it needs 8 to 12 weeks to show results.
- A temporary purge in the first few weeks is common and not a reason to stop.
- Pairing it with benzoyl peroxide at a different time of day covers both prevention and bacterial control.
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Source: SkinLabs Editorial Team ()
Cover image: Mathilde Langevin — credit