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Prescription Tretinoin: The Complete Beginner's Guide

By Michael C. · Written and reviewed by Michael C.

Retinoids · Published 2026-08-11 · 11 min read · 1973 words · Updated 2026-09-08

Tretinoin is pure retinoic acid and the most evidence-backed topical treatment for acne and photoageing, but it needs a slow, prescribed approach.

Key takeaways

  • Tretinoin is active retinoic acid itself, needing no conversion, making it stronger and faster-acting than retinol or retinaldehyde.
  • It requires a prescription in South Africa and typically starts at 0.025 percent, increasing gradually over months.
  • A purging phase of dryness and flaking is common and expected in the first several weeks.
  • Daily broad-spectrum sunscreen is essential throughout treatment due to increased photosensitivity.

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Source: SkinLabs Editorial Team ()

Cover image: Kitera Dent — credit