Brightening ·

Moderate evidence

Acetyl Glucosamine

What is it?

N-Acetyl Glucosamine (NAG) is a stable amino-sugar derivative of glucosamine, used in skincare formulations aimed at uneven skin tone for its studied effect on the pigmentation pathway.

What does it do?

In a randomized, double-blind, placebo-controlled split-face trial, 2% topical N-Acetyl Glucosamine reduced the appearance of facial hyperpigmentation over 8 weeks, with a greater effect when combined with 4% niacinamide.

How to use

Typically formulated at around 2%, often combined with niacinamide.

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Sources

Important disclaimer

This page provides general skincare information and is not medical advice, diagnosis or treatment. Ingredient interactions and evidence summaries reflect published, cited sources — not a personal assessment of your skin. For medical skin conditions, rashes, pregnancy/lactation questions or persistent concerns, please consult a licensed dermatologist or HPCSA-registered practitioner.