Peptide ·
Argireline
INCI: Acetyl Hexapeptide-8
What is it?
Acetyl Hexapeptide-8 (marketed as Argireline) is a synthetic peptide modeled on part of the SNAP-25 protein, studied for a modest effect on the neuromuscular signaling associated with expression lines -- a mechanism often compared to, but far milder than, botulinum toxin injections.
What does it do?
A randomized, placebo-controlled trial in Chinese subjects found a 48.9% subjective improvement in peri-orbital (crow's feet) wrinkles after twice-daily application for 4 weeks, versus 0% in the placebo group, with objective skin-roughness measurements also improving.
How to use
Skin penetration is highly dependent on the delivery vehicle -- research comparing emulsion types found multiple water-in-oil-in-water formulations enhanced delivery into skin compared to simple oil-in-water or water-in-oil emulsions.
Real products containing this
Sources
This page provides general skincare information and is not medical advice, diagnosis or treatment. Ingredient interactions and evidence summaries reflect published, cited sources — not a personal assessment of your skin. For medical skin conditions, rashes, pregnancy/lactation questions or persistent concerns, please consult a licensed dermatologist or HPCSA-registered practitioner.