Baicalin

What is it?

A flavonoid extracted from the root of Scutellaria baicalensis, studied for anti-inflammatory effects on skin, including in inflammatory skin conditions.

What does it do?

According to PubMed, a 2023 study found that topical application of baicalin reduced erythema, scaling and epidermal thickness in a mouse model of imiquimod-induced psoriasis-like skin inflammation, decreasing levels of the inflammatory cytokines IL-17A, IL-22, IL-23 and TNF via the IL-17/IL-23 axis (DOI: https://doi.org/10.1055/a-0622-8242). A separate 2023 study found topical baicalin combined with echinacoside ameliorated psoriatic skin lesions in the same mouse model by suppressing TNF and VEGF signalling pathways (DOI: https://doi.org/10.1021/acsomega.3c04281). Both are real preclinical (mouse model) studies; no human clinical trial was found.

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Important disclaimer

This page provides general skincare information and is not medical advice, diagnosis or treatment. Ingredient interactions and evidence summaries reflect published, cited sources — not a personal assessment of your skin. For medical skin conditions, rashes, pregnancy/lactation questions or persistent concerns, please consult a licensed dermatologist or HPCSA-registered practitioner.