Madecassoside

What is it?

A triterpene compound derived from Centella asiatica, studied for its role in skin wound healing and protecting keratinocytes from UV damage, distinct from the already-catalogued whole Centella Asiatica extract.

What does it do?

According to PubMed, a 2025 in-vitro study using human keratinocyte (HaCaT) cell cultures found madecassoside enhanced wound healing and protected cells against UVB-induced apoptosis and loss of viability, acting through calcium-, AMPK- and mTOR-dependent ERK signalling pathways (DOI: https://doi.org/10.1080/21688370.2025.2532229). This is real but preclinical (cell-culture) evidence; no human clinical trial specifically isolating madecassoside's effect was found.

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Sources

Phytochemical Madecassoside enhances skin wound healing and protects against UVB-induced keratinocyte damage

Important disclaimer

This page provides general skincare information and is not medical advice, diagnosis or treatment. Ingredient interactions and evidence summaries reflect published, cited sources — not a personal assessment of your skin. For medical skin conditions, rashes, pregnancy/lactation questions or persistent concerns, please consult a licensed dermatologist or HPCSA-registered practitioner.