Natural Moisturizing Factors

What is it?

Natural Moisturizing Factors (NMF) are a group of water-binding compounds (amino acids, lactic acid, urea, PCA and others) naturally present in the stratum corneum, used as a formulation concept in skincare to help replenish and mimic the skin's own hydration system.

What does it do?

Commonly used as a humectant concept to replenish the skin's own moisture-binding compounds, particularly important in barrier-impaired conditions like atopic dermatitis. A prospective cohort study using confocal Raman spectroscopy found moisturizers and emollients affect stratum corneum molecular composition differently over time in patients with reduced natural moisturizing factors versus those without.

Real products containing this

Natural Moisturizing Factors + HA — The Ordinary

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Sources

Effects of a Moisturizer and Emollient on the Stratum Corneum Assessed by Confocal Raman Spectroscopy in Patients With and Without Atopic Dermatitis

Important disclaimer

This page provides general skincare information and is not medical advice, diagnosis or treatment. Ingredient interactions and evidence summaries reflect published, cited sources — not a personal assessment of your skin. For medical skin conditions, rashes, pregnancy/lactation questions or persistent concerns, please consult a licensed dermatologist or HPCSA-registered practitioner.