Matrixyl 3000 component

INCI: Palmitoyl Pentapeptide-4

What is it?

A signal peptide from the widely used "Matrixyl" peptide family, marketed to support collagen signalling and reduce the visible appearance of wrinkles.

What does it do?

According to PubMed, a 2025 study developed a glycyrrhizic-acid-based ionic-liquid nanomicelle delivery system to improve skin permeation of palmitoyl pentapeptide-4 (PAL-4), finding that in cellular and animal photoaging models the delivered peptide boosted collagen and hyaluronic acid regeneration, reduced inflammation and apoptosis, and lessened skin wrinkles while improving elasticity (DOI: https://doi.org/10.1002/advs.202412581). This is real but preclinical (cell- and animal-model) evidence centered on a delivery-system innovation rather than a human clinical trial of the peptide alone.

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Sources

Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides

Important disclaimer

This page provides general skincare information and is not medical advice, diagnosis or treatment. Ingredient interactions and evidence summaries reflect published, cited sources — not a personal assessment of your skin. For medical skin conditions, rashes, pregnancy/lactation questions or persistent concerns, please consult a licensed dermatologist or HPCSA-registered practitioner.