Palmitoyl Tripeptide-1

What is it?

A signal peptide used in anti-aging formulations to support the skin's own collagen production, part of the widely studied "Matrixyl" peptide family.

What does it do?

According to PubMed, a 2026 study found collagen metabolism in skin fibroblasts follows a circadian rhythm, and that applying palmitoyl tripeptide-1 specifically at night (timed to when collagen synthesis genes peak) produced measurable clinical improvements in a 30-person trial: skin luminance improved 16.29%, nasolabial fold depth decreased 36.35%, and firmness improved 24.35% -- real, recent clinical-trial evidence, though for a specific day/night-timed regimen alongside a second active (baicalin) rather than palmitoyl tripeptide-1 used alone.

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Sources

Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism

Important disclaimer

This page provides general skincare information and is not medical advice, diagnosis or treatment. Ingredient interactions and evidence summaries reflect published, cited sources — not a personal assessment of your skin. For medical skin conditions, rashes, pregnancy/lactation questions or persistent concerns, please consult a licensed dermatologist or HPCSA-registered practitioner.