Leuphasyl

INCI: Pentapeptide-18

What is it?

A neuromodulatory ("Botox-like") peptide marketed under the trade name Leuphasyl, studied for reducing expression-line wrinkles by inhibiting neurotransmitter release at the neuromuscular junction, distinct from Acetyl Octapeptide-3.

What does it do?

According to PubMed, a 2026 computational and spectroscopic study used molecular docking and dynamics simulations to characterize Pentapeptide-18's binding to several molecular pathways implicated in skin aging (TGF-beta, TNF-alpha, MAPK, PI3K/AKT, NF-kB), providing mechanistic support for its reported ability to reduce wrinkle formation and improve skin hydration, elasticity and texture (DOI: https://doi.org/10.1016/j.compbiolchem.2026.108952). This is a computational/structural characterization study rather than a human clinical trial; no dedicated RCT for this specific peptide was found in this search.

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Sources

Pentapeptide-18 as an anti-aging candidate: Spectroscopic characterization and molecular interaction analysis

Important disclaimer

This page provides general skincare information and is not medical advice, diagnosis or treatment. Ingredient interactions and evidence summaries reflect published, cited sources — not a personal assessment of your skin. For medical skin conditions, rashes, pregnancy/lactation questions or persistent concerns, please consult a licensed dermatologist or HPCSA-registered practitioner.