Humectant ·
Polyglutamic Acid
What is it?
Polyglutamic acid (poly-gamma-glutamic acid, gamma-PGA) is a naturally derived, water-soluble biopolymer produced by fermentation, used in skincare as a humectant valued for its high water-binding capacity.
What does it do?
Commonly used as a humectant to strengthen the skin barrier and improve moisture retention. A study using keratinocyte cultures and a reconstructed skin model found gamma-PGA dose-dependently increased expression of skin barrier markers (filaggrin, involucrin, loricrin), though this evidence is preclinical (cell/tissue-model) rather than from a human clinical trial.
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This page provides general skincare information and is not medical advice, diagnosis or treatment. Ingredient interactions and evidence summaries reflect published, cited sources — not a personal assessment of your skin. For medical skin conditions, rashes, pregnancy/lactation questions or persistent concerns, please consult a licensed dermatologist or HPCSA-registered practitioner.