SkinLabs Knowledge Hub
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Routines
Yes — you can use both in the same overall routine. The simplest, lowest-irritation default is vitamin C in the morning under sunscreen, retinol at night, so you're not layering two potentially irritating actives in one application. Some formulations are gentle enough to use closer together, but if your skin is sensitive or new to actives, keeping them on separate shifts is the safer starting point.
Evidence reviewed · Aug 2026
- DermNet NZ — combining topical activesDermNet
AM/PM separation rationale for retinoids and vitamin C
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Content last reviewed 31 August 2026 by the SkinLabs Editorial Team.